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Alpidem (Ananxyl) 1995. Worldwide. Not approved in the US, withdrawn in France in 1994 [4] and the rest of the market in 1995 because of rare but serious hepatotoxicity. [3] [5] Alosetron (Lotronex) 2000. US. Serious gastrointestinal adverse events; ischemic colitis; severe constipation. [2]
Rank Drug Main indication Trade name 2018 sales (million USD) 2017 sales (million USD) 1 adalimumab: rheumatoid arthritis: Humira 19 936 18427 3 apixaban
The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses. The elimination half-life is how long it takes for half ...
Ranitidine is an H 2 histamine receptor antagonist that works by blocking histamine, thus decreasing the amount of acid released by cells of the stomach. [12] Ranitidine was discovered in England in 1976, and came into commercial use in 1981. [26] It is on the World Health Organization's List of Essential Medicines.
Isotretinoin is the only non-psychiatric drug on the FDA 's top 10 list of drugs associated with depression [ 55][ 60] and is also within the top 10 for suicide attempts. [ 61] A black box warning for suicide, depression and psychosis has been present on isotretinoin's packaging in the United States since 2005. [ 60]
Website. www .gcsurplus .ca /mn-eng .cfm. GCSurplus is a Canadian government department responsible for handling moveable Crown assets that a federal department or agency has declared as surplus under the Surplus Crown Assets Act (R.S., c. S-20, s. 1). [1] Surplus assets are typically auctioned off to the public through the GCSurplus website.